PEDIATRICS Vol. 48 No. 4 October 1971, pp. 667-668
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Polio Vaccination in Developing Countries

Roy E. Brown M.D. M.P.H.1 and Michael Katz M.D.2

1 Department of Community Medicine, Mount Sinai School of Medicine of the City University of New York, New York, New York 10029
2 Columbia University, School of Public Health and Administrative Medicine, New York, New York 10027

We have recently come across the Letter to the Editor from Dr. Shanti Ghosh,1 commenting on the trivalent oral polio virus vaccine trials reported by Hardy, et al. in Pediatrics.2

Although 96 to 100% of infants demonstrated satisfactory levels of immunity in Hardy's group, using a microneutralization titer technique, Dr. Ghosh describes disappointing results in children in India and Nigeria as indicated by low seroconversion rates, as well as very low enterovirus excretion rate in pre- and postimmunization specimens (7.8%).