PEDIATRICS Vol. 48 No. 4 October 1971, pp. 647-650
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Decline in Serum Bilirubin Concentration Coincident with Clinical Onset of Kernicterus

Bruce D. Ackerman M.D.1, Geraldine Y. Dyer M.D.1, and Paul M. Taylor M.D.2

1 Department of Pediatrics, University of California, Irvine, College of Medicine, Irvine, California 92664
2 University of Pittsburgh, School of Medicine, 4200 Fifth Avenue, Pittsburgh, Pennsylvania 15213

A decline in serum bilirubin level, coincident with the onset of clinical signs, occurred in 4 of 13 infants with kernicterus. Such a decline in bilirubin level carries a poor prognosis, but occurs too late to be clinically valuable as an indication for exchange transfusion.

Sources of patient material were: University of California, Irvine, College of Medicine, Pediatric department: Los Angeles County General Hospital, White Memorial Hospital, Los Angeles, Orange County Medical Center, Orange, California; and University of Pittsburgh, School of Medicine, Pediatric department: Magee-Womens Hospital, Pittsburgh, Pennsylvania.