PEDIATRICS Vol. 48 No. 4 October 1971, pp. 636-639
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Ampicillinuria and Ampicillin Crystalluria

Joseph L. Potter M.D., Ph.D.1, Arthur G. Weinberg M.D.1, and Raymond West B.S., M.T. (A.S.C.P.)1

1 Department of Pathology, The Children's Hospital of Akron, Akron, Ohio 44308

Four patients with ampicillinuria and ampicillin crystalluria have been reported. The presence of ampicillin leads to false positive spots for leucine/isoleucine, phenylalanine, and beta-amino isobutyric acid in paper chromatograms of the urinary amino acids, and to a false-positive spot for phenylalanine in paper electrophoretograms. Crystalluria, due to ampicillin, is also described. Its significance remains to be determined.




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