PEDIATRICS Vol. 48 No. 4 October 1971, pp. 509-510
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RETROLENTAL FIBROPLASIA: THE PEDIATRICIAN'S DILEMMA

A. Patz M.D.1 and V. Everett Kinsey Ph.D.2

1 The Wilmer Institute, Johns Hopkins University, Medical School and Hospital, Baltimore, Maryland 21205
2 Institute of Biological Sciences, Oakland University, Rochester, Michigan 48063

Retrolental fibroplasia (RLF), which was unknown prior to the early 1940's, was first identified in premature infants by Terry in 1942.1 Within the short span of approximately 10 years, RLF had become one of the major causes of blindness in children throughout the world. The incrimination of oxygen in the early 1950's was demonstrated conclusively in a cooperative study performed in the United States in 1953-54 and published in 1956.2 The results of this study led to the general restriction of oxygen therapy, and the incidence of RLF subsequently decreased dramatically.

Avery and Oppenheimer3 in 1960 first reported that the mortality from hyaline membrane disease had increased in their nursery during the period of rigid curtailment of oxygen to prevent RLF.




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Y. Miyazaki, L. Van Leeuwen, and G. Van Leeuwen
Retrolental Fibroplasia: A Continuing Dilemma for the Pediatrician
Clinical Pediatrics, December 1, 1977; 16(12): 1091 - 1092.
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