PEDIATRICS Vol. 48 No. 3 September 1971, pp. 417-422
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bass, J. W.
Right arrow Articles by Dierdorff, E. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bass, J. W.
Right arrow Articles by Dierdorff, E. P.

ERYTHROMYCIN CONCENTRATIONS IN MIDDLE EAR EXUDATES

James W. Bass M.D., LTC MC1, Russell W. Steele M.D., MAJ MC1, Robert A. Wiebe M.D., MAJ MC1, and Edwin P. Dierdorff M.D., MAJ MC1

1 Pediatric Service, Department of Medicine and the Otolaryngology Service, Department of Surgery, U.S. Army Tripler General Hospital

Children with acute otitis media were treated with oral esters of erythromycin in doses of 12.5 mg/kg at 6-hour intervals for 24 hours (50 mg/kg/day). Two hours after the last dose serum and middle ear exudates obtained by needle aspiration were assayed for erythromycin levels. Gram stained smears and cultures of the middle ear exudates were obtained and correlated with the levels of erythromycin found in the exudates. Concentrations of the drug were found in middle ear exudates sufficient to be effective against essentially all strains of D. pneumoniae and Lancefield Group A beta hemolytic streptococci. These results may explain why erythromycin is highly effective in the treatment of acute otitis media due to these organisms. Penetration of erythromycin into middle ear exudates may not be sufficient in some cases to eradicate all strains of H. inflenzae and therefore otitis media due to this organism may not respond as readily to therapy with this agent.

Submitted on November 10, 1970
Accepted on March 11, 1971




This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
G. F. Hayden
Acute Suppurative Otitis Media in Children: Diversity of Clinical Diagnostic Criteria
Clinical Pediatrics, February 1, 1981; 20(2): 99 - 104.
[Abstract] [PDF]

Home page
 CLIN PEDIATRHome page
V. M. Howie and J. H. Ploussard
Efficacy of Fixed Combination Antibiotics versus Separate Components in Otitis Media: Effectiveness of Erythromycin Estolate, Triple Sulfonamide, Ampicillin, Erythromycin Estolate-Triple Sulfonamide, and Placebo in 280 Patients with Acute Otitis Media Under Two and One-Hal Years of Age
Clinical Pediatrics, April 1, 1972; 11(4): 205 - 214.
[Abstract] [PDF]