PEDIATRICS Vol. 48 No. 2 August 1971, pp. 307-312
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Colon Carcinoma in Childhood

Milton H. Donaldson M.D.1, Peyton Taylor M.D.2, Robert Rawitscher M.D.3, and John B. Sewell Jr M.D.4

1 Departments of Pediatrics ard Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22901
2 Department of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville, Virginia 22901
3 Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22901
4 Department of Radiology, University of Virginia School of Medicine, Charlottesville, Virginia 22901

Two cases of colon carcinoma in children without a family history of polyposis or gastrointestinal malignancy are reported. Details of the post-surgical treatment with 5-fluorouracil are stated, along with a brief recounting of the literature which served as a basis for the therapeutic approach utilized in these two patients. The tumor-free intervals of 14 and 20 months are impressive in view of the advanced stages of the lesions and, thus, suggest 5-FU should be utilized in children with colon cancer as it is in such adults.