PEDIATRICS Vol. 48 No. 2 August 1971, pp. 305-307
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Herpangina and Pleurodynia Associated with Herpes simplex Virus

Melvin I. Marks M.D.1

1 Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado

Herpangina and pleurodynia are usually associated with Coxsackie A and Coxsackie B virus infections respectively.l,2 Although echoviruses and other etiological agents have also been described with these syndromes, Herpes simplex virus has not.3,4 The present case is unique in two respects; herpangina and pleurodynia occurred simultaneously in the same patient and both appear to be associated with a primary Herpes simplex virus infection.

Report of a Case

A 15-year-old Caucasian male complained of sore throat with dysphagia 5 days prior to admission to hospital and 3 days later developed increased dvsphagia, malaise, anorexia, and a temperature of 103°F. The following day he complained of distressing retrosternal and left anterior pleuritic chest pain accompanied by nausea.