PEDIATRICS Vol. 48 No. 2 August 1971, pp. 200-206
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davis, L. E.
Right arrow Articles by Chin, T. D. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davis, L. E.
Right arrow Articles by Chin, T. D. Y.

CYTOMEGALOVIRUS MONONUCLEOSIS IN A FIRST TRIMESTER PREGNANT FEMALE WITH TRANSMISSION TO THE FETUS

Larry E. Davis M.D.1, Gerald V. Tweed M.D.1, John A. Stewart M.D.1, Michael T. Bernstein M.D.1, Gerald L. Miller M.D.1, Clifton R. Gravelle M.S.1, and Tom D. Y. Chin M.D.1

1 Ecological Investigations Program and Laboratory Division, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U.S.Department of Health, Education, and Welfare, Kansas City, Kansas, and Atlanta, Georgia, and General Hospital, Kansas City, Missouri

An understanding of the pathogenesis of congenital cytomegalovirus (CMV) infections is hampered by the fact that the majority of adult infections are subclinical. This prevents documentation of the time of fetal infection. In the instance described, a 17-year-old pregnant female developed cytomegalovirus mononucleosis during her first trimester. CMV was recovered from her convalescent urine at 12 weeks' gestation and from amniotic fluid at 21 weeks' gestation. Following a therapeutic abortion at 22 weeks' gestation, CMV was recovered from multiple fetal organs. Cord serum contained 14 mg/100 ml IgM which is elevated for a 22-week fetus.

The IgM fraction of the cord serum contained specific CMV antibodies as demonstrated by indirect hemagglutination and indirect immunofluorescence techniques. This suggests that, under abnormal circumstances such as intra-uterine infections, fetuses may be capable of synthesizing detectable levels of specific IgM antibodies as early as 22 weeks' gestation.

Submitted on November 12, 1970
Accepted on February 19, 1971




This article has been cited by other articles:


Home page
 ScienceHome page
E Gonczol, P. Andrews, and S. Plotkin
Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells
Science, April 13, 1984; 224(4645): 159 - 161.
[Abstract] [PDF]