PEDIATRICS Vol. 48 No. 1 July 1971, pp. 64-72
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PULMONARY MECHANICS IN ASTHMA AND CYSTIC FIBROSIS

Alois Zapletal M.D.1, Etsuro K. Motoyama M.D.1, Lewis E. Gibson M.D.1, and Arend Bouhuys M.D1

1 Departments of Pediatrics, Anesthesiology, and Medicine, Yale University School of Medicine, and the John B. Pierce Foundation Laboratory, New Haven, Connecticut

Maximum expiratory flow rates on flow-volume curves are often decreased below normal limits in children with asthma or cystic fibrosis who are clinically well and whose standard spirometric tests are within normal limits. In particular, maximum flow rates at small lung volumes (25% of vital capacity) are decreased. Maximum expiratory flow-volume (MEFV) curves provide a sensitive and quantitative assessment of small airway obstruction in these and other obstructive lung conditions.