PEDIATRICS Vol. 48 No. 1 July 1971, pp. 41-50
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LIVER SCANS IN CHRONIC GRANULOMATOUS DISEASE OF CHILDHOOD

L. D. Samuels M.D.1

1 Nuclear Medicine Laboratory, Children's Hospital and the Department of Pathology, Ohio State University

The biochemical defect of oxidase deficiency present in chronic granulomnatous disease of childhood is manifest clinically by recurrent infections, especially focal abscesses. In the liver these may be bacterial abscesses or characteriastic miliary, sterile granulomas. Either of these can be well-visualized and usefully followed with radioisotope liver scans.

Follow-up scans of the liver have shown that chronic changes of the disease may severely distort the gross liver morphology. Cases are presented of two surviving teen-age cousins and two young sisters, subsequently deceased, whose third sibling has just presented with the disease.




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