PEDIATRICS Vol. 48 No. 1 July 1971, pp. 159-160
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greensher, A.
Right arrow Articles by Robinson, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greensher, A.
Right arrow Articles by Robinson, A.

Intra-uterine Diagnosis of Fetal Sex

A. Greensher 1, R. Gersh 1, D. Peakman 1, and A. Robinson 1

1 Departments of Biophysics and Genetics, and Pediatrics, University of Colorado Medical Center, Denver, Colorado 80220

The ability to examine amniotic fluid obtained by amniocentesis during the second trimester of pregnancy is a significant new advance in the practice of clinical genetics.1 We here report a rapid and accurate method for determining fetal sex, which should be useful when the pregnant woman is a carrier of a serious sex-linked disease such as muscular dystrophy or hemophilia. The method makes use of the selective concentration of fluorescent stains by the Y chromosome in interphase cells.2,3 Recently two observers have reported their preliminary observations on amniotic fluid cells using fluorescent techniques.4,5