PEDIATRICS Vol. 48 No. 1 July 1971, pp. 141-144
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Disseminated BCG in Twin Boys with Presumed Chronic Granulomatous Disease of Childhood

John R. Esterly M.D.1, William Q. Sturner M.D.1, Nancy B. Esterly M.D.2, and Dorothy B. Windhorst M.D.3

1 Department of Pathology
2 Department of Pediatrics
3 Department of Medicine, The University of Chicago, Chicago, Illinois 60637

Twin male infants, immunized with BCG at birth, died at 4frac12 months and 9 months of age with dissemination of this organism, as well as other infections. Disorders of humoral and cellular immunity were excluded by laboratory findings, but evidence of defective phagocytic activity in a surviving relative strongly suggests that the twins represent the first known instance of BCG-osis complicating chronic granulomatous disease of childhood.




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