PEDIATRICS Vol. 47 No. 6 June 1971, pp. 1023-1028
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ELEVATED SERUM IgA GLOBULIN IN ANAPHYLACTOID PURPURA

Carl W. Trygstad M.D.1 and E. Richard Stiehm M.D.1

1 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, and the University of Wisconsin Medical School, Madison, Wisconsin

Serial determinations of serum levels of IgA, IgD, IgG, and IgM globulin were performed on 27 children with anaphylactoid purpura and two children with acute poststreptococcal glomerulonephritis. Ten of 20 children with anaphylactoid purpura seen within 3 months of the onset of the skin rash had significant elevations of their serum IgA globulin. The other immunoglobulin levels were normal in the remaining children and those with acute poststreptococcal glomerulonephritis.

The selective elevation of serum IgA globulin may be related to the pathogenesis of anaphylactoid purpura.

Submitted on June 8, 1970
Accepted on January 6, 1971




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