PEDIATRICS Vol. 47 No. 5 May 1971, pp. 848-856
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IgE LEVELS IN SERA OF CHILDREN WITH ASTHMA

Lata Kumar M.D.1, Richard W. Newcomb M.D.1, Kimishige Ishizaka M.D.1, Elliott Middleton Jr. M.D.1, and Margaret M. Hornbrook 1

1 Children's Asthma Research Institute and Hospital, Denver, Colorado

Concentrations of the immunoglobulin that is associated with reaginic activity, IgE (ggrE), were measured in sera of 116 children with bronchial asthma. High ggrE (>700 ng/ml) were found in only 30. High ggrE levels were found in children with many positive skin tests (P < 0.01) and with active atopic dermatitis (P < 0.01). Long term, systemic corticosteroid therapy was found to be associated with normal ggrE values (P < .001) even when the characteristics of the disease would otherwise have indicated high values.

As no correlation is found to be evident between severity of the disease and ggrE levels, it may be suggested that corticosteroids may decrease intravascular ggrE. The serum ggrE values failed to reveal two or more clinically different groups among our patients.

Submitted on September 30, 1970
Accepted on December 7, 1970