PEDIATRICS Vol. 47 No. 5 May 1971, pp. 839-843
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wakonig-Vaartaja, T.
Right arrow Articles by Murphy, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wakonig-Vaartaja, T.
Right arrow Articles by Murphy, M. L.

CYTOGENETIC OBSERVATIONS IN CHILDREN WITH NEUROBLASTOMA

Theresa Wakonig-Vaartaja Ph.D.1, Lawrence Helson M.D.1, Ann Baren B.Sc.1, Leopold G. Koss M.D.1, and M. Lois Murphy M.D.1

1 Cytology Service, Department of Pathology, and the Department of Pediatrics, Memorial Hospital for Cancer and Allied Diseases; and from the Sloan-Kettering Institute for Cancer Research, New York

Cytogenetic studies were performed on 21 children with neuroblastoma. Increased numbers of abnormal metaphases were observed in pretreatment samples of peripheral blood and bone marrow. Three bone marrows infiltrated with extrinsic cells had heteroploid cell lines with consistent marker chromosomes. Long-term survivors without evidence of active disease had chromosomal abnormalities in peripheral blood lymphocytes.

These findings evoke questions concerning prognosis, tumor formation, and long-term effects of radiotherapy.

Submitted on August 20, 1970
Accepted on December 16, 1970