PEDIATRICS Vol. 47 No. 4 April 1971, pp. 689-697
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DEVELOPMENT OF CHILDREN WHO HAD RECEIVED INTRA-UTERINE TRANSFUSIONS

R. H. Phibbs M.D.1, D. Harvin B.A.1, G. Jones M.A.1, C. Talbot M.A.1, M. Cohen M.S.W.1, D. Crowther M.D.1, and W. H. Tooley M.D.1

1 Departments of Pediatrics, Neurology, Otolaryngology, and the Cardiovascular Research Institute, University of California, San Francisco

Sixty-six nonhydropic fetuses received intra-uterine transfusions for severe erythroblastosis fetalis; 24 survived the neonatal period–the youngest is now more than 1 year and the oldest 5 years of age. Serial evaluations of growth and development of the survivors were compared with their course in the perinatal period. Twenty-one were normal; one suffered severe central nervous system damage associated with severe cardiorespiratory failure, prolonged acidosis, and hypoxia during the neonatal period; one has a handicap due to hearing loss and one has a speech handicap. The results support the use of intra-uterine transfusion in appropriately selected fetuses when combined with aggressive treatment of cardiorespiratory distress and hyperbilirubinemia during the neonatal period.

Submitted on June 29, 1970
Accepted on November 28, 1970