PEDIATRICS Vol. 47 No. 4 April 1971, pp. 658-665
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EXPERIMENTAL SALICYLATE POISONING: OBSERVATIONS ON THE EFFECTS OF ALTERING BLOOD pH ON TISSUE AND PLASMA SALICYLATE CONCENTRATIONS

John B. Hill M.D., Ph.D.1

1 Center for Research in Pharmacology and Toxicology, School of Medicine, University of North Carolina, and The Becton Dickinson Research Center, Raleigh, North Carolina

Sprague-Dawley rats were infused with sodium salicylate followed by saline, bicarbonate, or carbon dioxide inhalation. Bicarbonate raised the blood pH and lowered the muscle, brain and liver salicylate concentrations compared with the saline controls. Carbon dioxide inhalation produced the opposite effect.

Acetazolamide lowered the blood pH, raised the tissue salicylate levels, and increased the toxicity of sodium salicylate. If the systemic acidosis produced by acetazolamide was prevented with bicarbonate, the rise in tissue salicylate was also prevented.

Submitted on August 17, 1970
Accepted on December 11, 1970




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