PEDIATRICS Vol. 47 No. 3 March 1971, pp. 613-622
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Omenn, G. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Omenn, G. S.

ECTOPIC HORMONE SYNDROMES ASSOCIATED WITH TUMORS IN CHILDHOOD

Gilbert S. Omenn M.D.1

1 Division of Medical Genetics, University of Washington, Seattle, Washington

Ectopic production of hormones by tumors can serve as a clue to diagnosis of the tumor and as a focus for management of the patient.

Impressive numbers of cases of hypercortisolism, hypoglycemia, precocious puberty, and hypercalcemia due to tumors of nonendocrine tissues have been reported in children already, and it is likely that many others go unrecognized.

The types of tumors and the effects of ectopic hormones in children are quite similar to those in adults, though the tumors most commonly associated reflect the relative frequencies of those tumors in the different age groups.

The unifying hypothesis of genetic derepression accounts for the ectopic hormone syndromes and predicts that additional unusual tumor products can be detected.

Submitted on October 9, 1970
Accepted on November 4, 1970




This article has been cited by other articles:


Home page
 NEJMHome page
B. Hirshberg, P. M. Conn, G. I. Uwaifo, K. L. Blauer, B. D. Clark, and L. K. Nieman
Ectopic Luteinizing Hormone Secretion and Anovulation
N. Engl. J. Med., January 23, 2003; 348(4): 312 - 317.
[Full Text] [PDF]