PEDIATRICS Vol. 47 No. 3 March 1971, pp. 587-593
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ALDOSTERONE SECRETION RATES IN CHILDREN WITH NORMAL ADRENAL FUNCTION

George T. Bryan M.D.1

1 Department of Pediatrics, Division of Endocrinology, and the Clinical Study Center, University of Texas Medical Branch, Galveston

Aldosterone secretion rate (ASR) was measured in 17 children during low, normal, and high dietary sodium intakes. Their ages varied from 3 months to 16 years; there were eight girls and nine boys. The average ASR with low, normal, and high sodium intakes were 236, 77, and 18 µg/ day respectively. The independent contribution of patient age, sex, sodium and potassium intake, and duration of fixed sodium intake was tested by least squares multiple regression analysis. The most important independent variable was sodium intake, although the sex and age of the patient were statistically significant variables. From this study it seems unlikely that precise control of all nutrients is necessary for evaluation of ASR if careful attention is paid to sodium intake.

Submitted on November 7, 1969
Accepted on September 20, 1970