PEDIATRICS Vol. 47 No. 3 March 1971, pp. 548-557
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RENAL HOMOTRANSPLANTATION IN PEDIATRIC PATIENTS

John R. Lilly M.D.1, Geoffrey Giles M.D.1, Richard Hurwitz M.D.1, Gerhard Schroter M.D.1, Hiroshi Takagi M.D.1, Samuel Gray M.D.1, Israel Penn M.D.1, Charles G. Halgrimson M.D.1, and Thomas E. Starzl M.D., Ph.D.1

1 Departments of Surgery and Pediatrics, University of Colorado Medical Center, Denver, Colorado

Fifty-seven patients were treated with renal homotransplantation from 1frac12 to 7frac23 years ago; 23 patients were 12 years or younger and the other 34 patients were 13 to 18. Family members (usually parents) were the primary donors in 45 cases. Unrelated volunteers or cadavers donated the other 12 homografts. Immunosuppression was with azathioprine and prednisone, and in some cases also with ALG. Forty-two of the 57 recipients survived for at least 1 year. Additional deaths occurred at 17frac12 and 19 months leaving 40 recipients (70.2%) alive. Six survivors had successful retransplantation following late failure of their original homografts. Control of rejection was not particularly different than in adult cases. "Homograft glomerulonephritis" was found in chronically tolerated transplants, but no more frequently than in older patients.

Many postoperative problems in the pediatric age group were the consequence of retardation of growth caused either by pre-existing uremia or by the need for high dose postoperative steroid therapy, orthopedic accidents such as femoral and vertebral fractures, and psychiatric complications which led to two suicides. In spite of these difficulties, the meaningful rehabilitation that was obtained in the chronic survivors makes us regard pediatric patients as favorable candidates for therapy with renal transplantation.

Submitted on May 29, 1970
Accepted on November 3, 1970




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