PEDIATRICS Vol. 47 No. 3 March 1971, pp. 516-519
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NEONATAL ADRENAL INSUFFICIENCY ASSOCIATED WITH MATERNAL CUSHING'S SYNDROME

Kenneth Kreines M.D.1 and William D. Devaux M.D.1

1 Jewish Hospital and the University of Cincinnati Medical Center and from the Children's Hospital, affiliated with the University of Cincinnati Medical Center, Cincinnati, Ohio

A female infant was delivered prematurely to a patient with Cushing's syndrome due to adrenal adenoma. At 20 hours of life the infant developed vascular collapse, hyponatremia, and hyperkalemia. These features of adrenal insufficiency responded promptly to the administration of hydrocortisone and saline. At 7 weeks, responsiveness of the infant's adrenal cortices to exogenous ACTH was demonstrated. Steroid replacement was subsequently discontinued and the infant has remained well.

Attention is drawn to the unusually high prevalence of adrenal adenoma and carcinoma among the reported cases of pregnancy during Cushing's syndrome.

Submitted on June 22, 1970
Accepted on August 24, 1970