PEDIATRICS Vol. 47 No. 2 February 1971, pp. 399-404
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DEFICIENCY OF IgM

W. P. Faulk M.D.1, W. S. Kiyasu M.D.1, M. D. Cooper M.D.1, and H. H. Fudenberg M.D.1

1 Departments of Pediatrics and Medicine, University of California, San Francisco; and Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama

An 8frac12-month-old infant with absent IgM had recurrent Pseudomonas infections. IgG and IgA, but no IgM-containing plasma cells, were identified in the spleen by immunofluorescence. The spleen and lymph nodes lacked germinal centers, but Peyer's patches and the appendix were normal. The absence of IgM was perhaps genetically determined because the father's serum IgM was also low. This may have predisposed to the Pseudomonas infection, since antibodies to Pseudomonas are predominantly IgM.

Submitted on February 11, 1970
Accepted on October 10, 1970