PEDIATRICS Vol. 47 No. 2 February 1971, pp. 352-359
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gervais, M.
Right arrow Articles by Drummond, K. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gervais, M.
Right arrow Articles by Drummond, K. N.

IMMUNOFLUORESCENT AND HISTOLOGIC FINDINGS IN THE HEMOLYTIC UREMIC SYNDROME

Marc Gervais M.D., C.M., M.Sc.1, John B. Richardson M.D., C.M., F.R.C.P.(C)1, Jane Chiu M.B.1, and Keith N. Drummond M.D., C.M., F.R.C.P.(C)1

1 Renal Laboratory, McGill University–Montreal Children's Hospital Research Institute, and the Department of Pathology, Montreal Children's Hospital, Montreal, Canada

Pathologic and immunopathologic studies were done in four patients with the hemolytic uremic syndrome. The principal lesions involved the endothelial and subendothelial regions of the renal arterioles and of the glomerular capillaries. The endothelial cells were swollen and, in the case of the glomerular capillary loops, separated from the basement membrane by an accumulation of material in the subendothelial space. In contrast to the glomerular capillaries, the endothelial changes in the renal arterioles were associated with a striking deposition of fibrinogen or its derivatives. No evidence for the operation of immune mechanisms of the type known to be associated with the development of vascular pathology was found to account for the microangiopathy.

Submitted on June 16, 1970
Accepted on October 26, 1970




This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
J.E. Musgrave, Y.B. Talwalkar, H.C. Puri, R.A. Campbell, and B. Loggan
Clinical Review: The Hemolytic-Uremic Syndrome: A Clinical Review
Clinical Pediatrics, March 1, 1978; 17(3): 218 - 225.
[PDF]