PEDIATRICS Vol. 47 No. 1 January 1971, pp. 134-135
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Cardiac Arrhythmia in a Child Due to Chloral Hydrate Ingestion

A. Nordenberg M.D.1, G. Delisle M.D.1, and T. Izukawa M.D.1

1 Department of Cardiology, The Hospital for Sick Children, 555 University Avenue, Toronto 101, Ontario, Canada

The recommended hypnotic dose of chloral hydrate depresses the cerebral hemisphere and induces sleep without significant change in respiration, blood pressure, or heart rate. With higher doses the respiratory rate may be depressed and the blood pressure reduced due to inedullary depression and peripheral cutaneous vasodilation.1,2

Chloral hydrate "in large doses depresses the contractility of the myocardium and shortens the refractory period."1 Toxic doses produce untoward cardiac effects especially in patients with heart disease.1

Reports of significant cardiac arrhythmia caused by chloral hydrate are rare.3-5. We present what we believe to be the first report of serious cardiac arrhythmia caused by chloral hydrate in a child.




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[Abstract] [PDF]