PEDIATRICS Vol. 47 No. 1 January 1971, pp. 132-134
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Severe Postural Hypotension Due to Imipramine Therapy

George W. Koehl M.D.1 and James E. Wenzel M.D.1

1 Department of Pediatrics, Children's Memorial Hospital, University of Oklahoma Medical Center, 800 N.E. 13th Street, Oklahoma City, Oklahoma 73104

The use of imipramine in the treatment of childhood enuresis has recently gained wide acceptance. The drug is known to be quite toxic to children who accidentally ingest it.1-4 Instances of incapacitating toxic effects caused by therapeutic dosages of the drug have not, to the best of our knowledge, been reported in children. It is our purpose to report a case of severe postural hypotension associated with therapeutic dosages of this drug.

Report of a Case

A 9-year-old Caucasian female was evaluated because of enuresis which had been present since toilet training was begun at age 2 years. A complete history and physical examination were nonrevealing; her pulse was 82 beats per minute and blood pressure was 110/75 mm Hg.




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H. Gil Rushton
Older Pharmacologic Therapy for Nocturnal Enuresis
Clinical Pediatrics, July 1, 1993; 32(1_suppl): 10 - 13.
[Abstract] [PDF]