PEDIATRICS Vol. 47 No. 1 January 1971, pp. 105-112
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ADRENERGIC NEURONE AND RECEPTOR ACTIVITY IN THE IRIS OF THE NEONATE

Norma Lind B.Sc.1, Elliot Shinebourne M.D., M.R.C.P.1, Paul Turner M.D., B.Sc., M.R.C.P.1, and Denis Cottom M.A., M.B., F.R.C.P.1

1 Department of Clinical Pharmacology, St. Bartholomew's Hospital, and the Department of Paediatrics, St. Thomas' Hospital, London

In premature and full-term infants, the response of the dilator pupillae muscle to directly and indirectly acting sympathetic amines was measured.

Phenylephrine always produced a mydriasis, whereas the response to tyramine and hydroxyamphetamine, which was positively correlated with age, tended to be absent in the least mature, smaller babies. The results indicate that, in this situation, the end organ has the capacity to respond to the sympathetic neurohumoral transmitter, but that the synthesis, storage, or release of neuronal noradrenaline may be deficient.

Submitted on January 26, 1970
Accepted on July 15, 1970