PEDIATRICS Vol. 46 No. 6 December 1970, pp. 900-912
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hanson, J. S.
Right arrow Articles by Shinozaki, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hanson, J. S.
Right arrow Articles by Shinozaki, T.

HYBRID COMPUTER STUDIES OF VENTILATORY DISTRIBUTION AND LUNG VOLUME

I. Normal Newborn Infants

John S. Hanson M.D.1 and Tamotsu Shinozaki M.D.1

1 Cardiopulmonary Laboratory, Department of Medicine, and the Division of Anesthesia, Department of Surgery, University of Vermont College of Medicine, Burlington, Vermont

The applicability of a computerized, on-line, breath-by-breath nitrogen washout technique to respiratory studies in newborn infants is described. Reproducibility and accuracy of the system are entirely comparable to standards previously established in adult studies.

Methodology allows simple, rapid, and direct assessment of a newborn infant's functional residual capacity, the uniformity of inspired gas distribution, and longitudinal time changes in these parameters.

Studies in 40 normal infants > 2 to 128 hours of age have confirmed some previously published findings, but do not support the concept of very early establishment of optimal ventilatory distribution.

Coupled with hemodynamic and blood gas studies, results obtained by this technique can provide a thorough evaluation of an infant's cardiopulmonary status. It is anticipated that such studies will provide valuable help in guiding and assessing results of ventilatory assistance and pharmacologic interventions in the respiratory distress syndrome.

Submitted on December 19, 1969
Accepted on June 25, 1970