PEDIATRICS Vol. 46 No. 5 November 1970, pp. 776-780
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Infectious Mononucleosis and Reye's Syndrome: A Fatal Case with Studies for Epstein-Barr Virus

James J. Rahal Jr. M.D.1 and Gertrude Henle M.D.2

1 Infectious Diseases Service, Department of Medicine, New England Medical Center Hospital and Department of Pediatrics, Boston Floating Hospital, Boston, Massachusetts
2 Virus Laboratories at the Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

A 6-year-old boy developed toxic encephalopathy and severe hepatitis following the onset of infectious mononucleosis. The disease was fatal and autopsy showed brain edema, fatty necrosis of the liver, and a mononuclear infiltration of the liver, spleen, lymph nodes, and gastrointestinal tract. Impression smears of these organs and inoculation of organ suspensions into tissue culture failed to demonstrate antigens of the Epstein-Barr virus or to yield cytopathic effect. The patient's serum contained a high titer of antibody to Epstein-Barr virus.




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D. R. DuBois and R. L. Baehner
Infectious Mononucleosis Associated with Fatal Beta Hemolytic Streptococcal Infection
Clinical Pediatrics, August 1, 1979; 18(8): 511 - 512.
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