PEDIATRICS Vol. 46 No. 5 November 1970, pp. 748-759
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HODGKIN'S DISEASE IN THE FIRST DECADE OF LIFE

Stephen B. Strum M.D.1 and Henry Rappaport M.D.2

1 Department of Pathology, The Pritzker School of Medicine of the University of Chicago, and the Argonne Cancer Research Hospital,* Chicago, Illinois
2 Department of Pathology, The Pritzker School of Medicine of the University of Chicago, and the Argonne Cancer Research Hospital, Chicago, Illinois

This report is based on a study of 35 children with Hodgkin's disease. The longest survival periods were 9.8 years in a patient who has expired and 9 years in a patient who is still alive. Fourteen patients are still alive at the time of submission of this paper; the survival periods range from 0.2 to 9 years; 11 are known dead and their survival periods range from 0.3 to 9.8 years. The outcome in 10 cases is not known. A striking predominance of males was noted (91%). In 30 of 31 classifiable cases, the histologic sections showed either nodular sclerosing Hodgkin's disease or Hodgkin's disease with lymphocytic predominance.

Regardless of classification, a striking preponderance of mature lymphocytes in tissue sections was evident in most cases. These findings suggest that a particular host response characterizes the disease in the young.

Submitted on March 15, 1970
Accepted on June 9, 1970