PEDIATRICS Vol. 46 No. 3 September 1970, pp. 403-410
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LONG-TERM FOLLOW-UP OF CYTOMEGALIC INCLUSION DISEASE OF INFANCY

William Berenberg M.D.1 and George Nankervis Ph.D., M.D.1

1 Department of Pediatrics, Harvard Medical School and the Department of Medicine, Children's Hospital Medical Center, Boston

Twelve children with cytomegalic inclusion disease (CID) of infancy were reevaluated at ages ranging from 3 to 12 years. Nine manifested significant mental and/or motor retardation while three did not have significant neuromuscular residual deficit. In general those infants with CID who demonstrated microcephaly, chorioretinitis, and intracranial calcification continued to exhibit these changes on follow-up while those free of these phenomena in infancy did not subsequently develop such changes. No significant abnormalities were encountered in studies of hematologic, renal, or hepatic function. Late mortality did not occur except as a consequence of severe neurologic disability. Fifteen children born of mothers who had had a previous child afflicted with CID were normal. The mothers remained well, although they had nine miscarriages after the birth of the affected infant, while none had occurred previously.

Submitted on November 28, 1969
Accepted on April 14, 1970




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