PEDIATRICS Vol. 46 No. 2 August 1970, pp. 315-316
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Letter To The Editor

Heinz F. Eichenwald M.D.1

1 University of Texas, Southwestern Medical School, Dallas, Texas 75235

Dr. Franciosi raises a point which deserves emphasis: antimicrobial therapy is not a static process; the widespread use of an antibiotic will often result in emergence of resistant bacteria necessitating continuous review of recommendations for therapy. The emergence of resistance of gram-negative enterobacteria to kanamycin, including not only E. coli but also klebsiella-aerobacter, has been reported to us from a number of areas in the United States and is recorded in scattered reports in the literature.