PEDIATRICS Vol. 46 No. 2 August 1970, pp. 314-315
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Preferable Antibiotics for Neonatal Sepsis

Ralph A. Franciosi M.D.1

1 Children's Hospital, 1056 East Nineteenth Avenue Denver, Colorado

A recent survey (see Figure 1) of antibiotic sensitivity of various organisms in our microbiology laboratory has raised a serious doubt in my mind as to the security most people may feel in treating neonatal sepsis with a combination of ampicillin and kanamycin. Since the majority of neonatal sepsis is secondary to gram negative organisms, particularly E. coli, our finding that 66.6% of E. coli were sensitive to kanamycin and 63.7% to ampicillin was bothersome.