PEDIATRICS Vol. 46 No. 1 July 1970, pp. 123-128
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Sex-Linked Cleft Palate in a British Columbia Indian Family

R. B. Lowry M.B., B.CH., F.R.C.P.(C)1

1 The Division of Medical Genetics Department of Paediatrics, University of British Columbia, 715 West 12th Avenue Vancouver 9, British Columbia, Canada

An Indian family from British Columbia is described in which 12 males have an incomplete cleft of the secondary palate, some belonging to the submucous variety. The symptoms and signs which should prompt a physician to make this diagnosis are nasal regurgitation of fluids in infancy, nasal speech, repeated attacks of otitis media, bifid uvula, and a palpable notch in the posterior edge of the hard palate. It is suggested that this type of cleft is the result of a sex-linked gene.




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