PEDIATRICS Vol. 45 No. 6 June 1970, pp. 945-949
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RIBOFLAVIN ABSORPTION AND EXCRETION IN THE NEONATE

William J. Jusko Ph.D.1, Narinder Khanna M.D.1, Gerhard Levy Pharm.D.1, Leo Stern M.D.1, and Sumner J. Yaffe M.D.1

1 Departments of Pharmaceutics and Pediatrics, State Unirersity, of New York at Buffalo, and the Department of Pediatrics, McGill University School of Medicine, Montreal

The absorption and excretion of riboflavin, a vitamin which is absorbed in adults by a saturable transport process in the proximal small intestine, was investigated in healthy, 5-day-old infants. After oral administration of a saturation dose of the vitamin (150 mg/sq m), the urinary recoveries of riboflavin in the neonates were similar (about 7% of the dose) to those obtained previously in 3-to 6-month-old infants. However, the maximum excretion rate (per unit of body surface area) of riboflavin was much lower and the duration of maximum excretion rates was much longer in the neonates than in older infants. Data obtained after parenteral administration of riboflavin show that the low maximum excretion rate was not due to limited renal capacity and that the longer duration of excretion was due to prolonged absorption of the vitamin from the intestinal tract.

Submitted on November 18, 1969
Accepted on February 5, 1970




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C. K. Kumar, N. Yanagawa, A. Ortiz, and H. M. Said
Mechanism and regulation of riboflavin uptake by human renal proximal tubule epithelial cell line HK-2
Am J Physiol Renal Physiol, January 1, 1998; 274(1): F104 - F110.
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