PEDIATRICS Vol. 45 No. 5 May 1970, pp. 847-850
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Quantitative Determination of Water-Soluble Proteins in Meconium

Allyn H. Rule Ph.D.1, Daniel T. Baran B.A.1, and Harry Shwachman M.D.2

1 Boston College Graduate Department of Biology, Chestnut Hill, Massachusetts
2 Departments of Clinical, Laboratories and Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

A quantitative microcomplement fixation assay and quantitative protein determinations were used to determine albumin as a percentage of total soluble proteins in meconium. Significant differences (p < 0.001 ) were found between the meconium from infants who develop the symptoms of cystic fibrosis (CF) and between healthy siblings of known patients with CF or normal controls. No statistical differences were seen between newborn infants with CF requiring surgical intervention due to meconium ileus and those not requiring surgery.