PEDIATRICS Vol. 45 No. 4 April 1970, pp. 715-716
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Letter To The Editor

Margaret H. D. Smith M.D.1

1 New Orleans, Louisiana

For the American Academy of Pediatrics, Committee on Control of Infectious Diseases, Dr. Margaret H. D. Smith commented as follows:

The patient reported by Lintermans and Sehynaeve is indeed perplexing, and is hard to clarify in retrospect. Several questions arise:

Why was the antituberculosis therapy which the patient was receiving ineffective? The tubercle bacilli recovered in November after 2 to 3 months of treatment with INH and streptomycin were INH resistant. While INH resistance not infrequently develops during therapy in patients with cavitary tuberculosis, where the populations of tubercle bacilli are huge, it rarely if ever develops during treatment in children with primary tuberculosis.