PEDIATRICS Vol. 45 No. 1 January 1970, pp. 129-130
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I. CLINICAL AND PSYCHOLOGICAL EFFECTS OF MARIJUANA IN MAN

A. T. Weil , N. E. Zinberg , and J. M. Nelsen

Not to prove or disprove popularly held ideas on marijuana, but to collect "some long overdue pharmacological data," a series of experiments on acute marijuana (cannabis sativa) intoxication were conducted in 1968 in the Behavioral Pharmacology Laboratory of The Boston University School of Medicine.

Three previous studies, Siler, et al1., The La Guardia Report2, and Williams, et al3., had reported a variety of consequences, including minimum physiological response. No controls were provided, and there was no dosage control.

The authors present the first known controlled double-blind study. Nine subjects who had not smoked marijuana were found with extreme difficulty and after 2 months of interviewing among the Boston student population.