PEDIATRICS Vol. 44 No. 6 December 1969, pp. 912-921
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mitus, A.
Right arrow Articles by Fellers, F. X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mitus, A.
Right arrow Articles by Fellers, F. X.

LONG-TERM FOLLOW-UP OF RENAL FUNCTIONS OF 108 CHILDREN WHO UNDERWENT NEPHRECTOMY FOR MALIGNANT DISEASE

Anna Mitus M.D.1, Melvin Tefft M.D.1, and Francis X. Fellers M.D.1

1 The Children's Cancer Research Foundation, The Children's Hospital Medical Center, and Harvard Medical School, Boston

To evaluate prognosis and to estimate the late effects of irradiation and chemotherapy on renal functions, renal studies were done on 108 children who underwent nephrectomy for malignant disease and were treated postoperatively with irradiation and chemotherapy. The time from nephrectomy to renal studies varied from less than 6 months to 18 years; the median time was 6.5 years. Postnephrectomy follow-up consisted of repeated urine examinations and cultures, clearances of endogenous creatinine, evaluations of Addis count and blood urea nitrogen, intravenous pyelograms, and radioisotopic renal scans with Hg197 tagged to chlormerodrin. The study indicated that normal renal functions could be preserved in pediatric patients after unilateral nephrectomy, irradiation, and administration of antitumor drugs, providing that irradiation of the remaining kidney was kept below 1,200 R. Although the incidence of urinary tract infections was higher than in normal children, no impairment of renal function followed, if adequate and prompt treatment was administered.

Submitted on September 23, 1968
Accepted on April 10, 1969