PEDIATRICS Vol. 44 No. 4 October 1969, pp. 606-609
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Antibiotics and Their Effect on Bordetella pertussis in the Nasopharynx

Peter J. Adasek M.D.1, Marie N. Meyer M.S.1, and C. George Ray M.D.1

1 Departments of Pediatrics and Microbiology University of Washington School of Medicine and Children's Orthopedic Hospital and Medical Center Seattle, Washington

Antibiotic therapy of varying dose, type, and duration was given to 11 infants and children with clinically and laboratory proven pertussis, and cultures and FA studies were used to determine their nasopharyngeal carriage of B. pertussis organisms. Nine of the 11 patients were found to still be harboring the organisms at the conclusion of the initial course of therapy.

It is recommended that patients with pertussis who are treated with antibiotics should not be assumed to be non-contagious after therapy is completed and that appropriate bacteriologic or FA studies are essential in determining whether nasopharyngeal carriage still exists.




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