PEDIATRICS Vol. 44 No. 4 October 1969, pp. 590-593
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BENIGN FAMILIAL HEMATURIA

Melvin I. Marks M.D., C.M.1 and Keith N. Drummond M.D., C.M., F.R.C.P.1

1 The Renal Laboratory, McGill University-Montreal Children's Hospital Research Institute, Montreal

Asymptomatic persistent renal hematuria of 6 months to 8 years' duration was observed in seven of eight siblings. There was no family history of renal disease or deafness, and other family members examined showed normal urinalyses; none of the other known forms of hereditary renal disease were detected. Abnormalities of renal function or general physical health and development were not detected. Renal biopsies were performed in the two patients with the longest history of hematuria (7 and 8 years). Light and immunofluorescence microscopic study of renal tissue revealed no abnormalities of glomeruhi or interstitial tissue.

This familial condition is characterized by persistent microscopic hematuria with episodic gross hematuria and a favorable long-term prognosis. Although the pathogenesis is unclear, an immune process does not appear to be involved. Microscopic examination of the urine of family members in hematuria without an obvious etiology is warranted.

Submitted on January 24, 1969
Accepted on April 17, 1969




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