PEDIATRICS Vol. 44 No. 4 October 1969, pp. 543-548
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THE ADSORPTION OF BILIRUBIN BY SEPHADEX AND ITS RELATIONSHIP TO THE CRITERIA FOR EXCHANGE TRANSFUSION

Nathan A. Kaufmann M.D.1, Jaime Kapitulnik M.S.1, and Solomon H. Blondheim M.D.1

1 Metabolic Laboratory and Department of Internal Medicine B, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, Israel

Small quantities of bilirubin (BR) were adsorbed by specially preparedh small columns of Sephadex G-25 from artificially jaundiced sera. The amount of bilirubin adsorbed from sera with bilirubin-albumin molar ratios between 1 and 2 was linearly related to the bilirubin concentration of the serum. There was no demonstrable adsorption of bilirubin by the column at ratios below 1.

Sephadex columns may be of value in determining the time when exchange transfusion should be performed to prevent kernicterus.

Submitted on January 20, 1969
Accepted on March 29, 1969




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J. Kapitulnik
Bilirubin: An Endogenous Product of Heme Degradation with Both Cytotoxic and Cytoprotective Properties
Mol. Pharmacol., October 1, 2004; 66(4): 773 - 779.
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