PEDIATRICS Vol. 43 No. 5 May 1969, pp. 858-865
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FAMILIAL PITUITARY DWARFISM ASSOCIATED WITH AN ABNORMAL SELLA TURCICA

Pierre E. Ferrier M.D.1 and E. Franklin Stone Jr. M.D.1

1 Department of Pediatrics, University of Washington, and the Children's Orthopedic Hospital and Medical Center (Joan Judson Research Laboratory and Retarded Children's Clinic), Seattle, Washington

Two non-twin sisters issued from healthy non-consanguineous parents of normal stature demonstrated severe growth failure, hypoglycemia, and evidence of deficiency of growth hormone, thyroid stimulating hormone (TSH), and adrenocorticotropic hormone (ACTH); in addition, they both had a very small sella turcica located in a sphenoid bone of abnormal morphology. This form of familial pituitary dwarfism is different from the genetic forms previously described.

Submitted on August 26, 1968
Accepted on December 10, 1968




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