PEDIATRICS Vol. 43 No. 5 May 1969, pp. 794-798
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STUDIES IN CYSTIC FIBROSIS: DETERMINATION OF SWEAT ELECTROLYTES IN SITU WITH DIRECT READING ELECTRODES

Louis Kopito M.S.1 and Harry Shwachman M.D.1

1 Division of Clinical Laboratories and the Department of Medicine, Children's Hospital Medical Center, the Department of Pediatrics, Harvard Medical School, and the Children's Cancer Research Foundation

An evaluation is made of newly developed specific-ion electrodes for determining sodium and chloride on the skin surface following the stimulation of the sweat glands by pilocarpine iontophoresis.

This procedure offers a rapid (5 to 6 minutes), convenient, and safe means for large-scale cystic fibrosis screening programs for screening infants and children.

Caution is urged in the evaluation of the reading since a failure to sweat may result in a misleading value.

Submitted on November 5, 1968
Accepted on December 16, 1968




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L. E. Gibson
The Decline of the Sweat Test: Comments on Pitfalls and Reliability
Clinical Pediatrics, August 1, 1973; 12(8): 450 - 453.
[Abstract] [PDF]