PEDIATRICS Vol. 43 No. 4 April 1969, pp. 635-636
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Letter to the Editor

Peter A. J. Adam M.D. and Robert Schwartz M.D.

In his letter to the Editor Robert C. Tibbs, criticizes our suggestion that inadequate information has been published to establish that phenformin is a beneficial adjunct to insulin therapy of diabetes mellitus in children. He cites his personal experience which confirms the impressions of several authors—that combined insulin-biguanide therapy plus the increased supervision such treatment entails has been associated with lowering of insulin dosage, stabilization of blood sugar, and reduction of the tendency to acidosis in a few "brittle" diabetic patients.