PEDIATRICS Vol. 43 No. 4 April 1969, pp. 567-572
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CLINICAL LABORATORY EXPERIENCES WITH A MORE ATTENUATED ENDERS' MEASLES VIRUS VACCINE (MORATEN) COMBINED WITH SMALLPOX VACCINE

Robert E. Weibel M.D.1, Joseph Stokes Jr. M.D., D.Sc.1, Eugene B. Buynak Ph.D.1, M. Bernice Leagus Ph.D.1, and Maurice R. Hilleman Ph.D., D.Sc.1

1 Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and the Division of Virus and Cell Biology Research, Merck Institute for Therapeutic Research, West Point, Pennsylvania

A premixed and lyophilized preparation of the more attenuated (Moraten) line of Enders' live measles virus vaccine combined with calf lymph smallpox vaccine was evaluated in a smallscale study in which the vaccine was given by jet gun. There was no evidence for interference between the two viruses. All the children responded serologically to both viruses and showed immune or vaccinoid reactions on challenge with smallpox vaccine given by the ordinary multiple puncture method. There was no apparent increase in clinical reaction beyond that expected following smallpox vaccine given alone.

Submitted on September 23, 1968
Accepted on November 18, 1968