PEDIATRICS Vol. 43 No. 4 April 1969, pp. 540-545
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ACQUIRED LACTOSE MALABSORPTION IN THAI CHILDREN

Gerald T. Keusch M.D.1, Frank J. Troncale 1, Louis H. Miller 1, Varuni Promadhat M.D.1, and Pearl R. Anderson Ph.D.1

1 Department of Clinical Research, SEATO Medical Research Laboratory, Bangkok, Thailand and the Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D.C.

One hundred seventy-two normal Thai infants and children were studied to determine the prevalence of lactose malabsorption and lactase deficiency. These abnormalities became manifest after infancy, and by age 2 years virtually all children studied were abnormal. Sucrase and maltase activities and sucrose and glucose absorption were normal in most. Calculation of ratios of median maltase/lactase, sucrase/lactase, and maltase/sucrase activities also indicated the major abnormality to be isolated lactase deficiency. Lactose malabsorption appeared earlier in life in a group of normal institution Thai children compared to a group of village children. This suggests that environmental factors may be important in the pathogenesis of lactase deficiency in Thai children, although genetic influences cannot be excluded.

Submitted on July 19, 1968
Accepted on November 15, 1968




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