PEDIATRICS Vol. 43 No. 3 March 1969, pp. 407-415
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A SIMPLE, RELIABLE METHOD OF MEASURING GLOMERULAR FILTRATION RATE USING SINGLE, LOW DOSE SODIUM IOTHALAMATE I131

Melvin L. Cohen M.D.1, Fred G. Smith Jr. M.D.1, Robert S. Mindell 1, and Robert L. Vernier M.D.1

1 Department of Pediatrics, UCLA School of Medicine, Los Angeles

The renal clearances of sodium iothalamate I131 after a single intravenous dose of 10 µCi were compared with inulin clearances and endogenous creatinine clearances. In a total of 40 comparative studies made between the isotope and inulin clearances, correlation was excellent (r = .995) with a very small standard error (±5.9), suggesting that sodium iothalamate I131 clearance accurately measures glomerular filtration rate. In 43 comparative studies between endogenous creatinine and inulin clearances, correlation was good (r = .935) only when determined simultaneously, and even then the standard error was so great (± 18.7) that any individual creatinine clearance was of limited value.

In performing the isotope clearance, adequate hydration is maintained orally. Ten microcuries of sodium iothalamate I131 are injected intravenously. After a 30 to 60 minute equilibration period, the bladder is emptied by voiding and a blood specimen obtained. A timed, voided urine is then collected and again a blood specimen obtained at the time of voiding. Both blood specimens and the urine are counted in a well-type scintillation counter with gamma spectrometer. The mean of the beginning and end-point plasma radioactivity is used in the clearance formula. This isotope method is recommended as the test of choice in measuring glomerular filtration rate.

Submitted on August 7, 1968
Accepted on October 29, 1968




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