PEDIATRICS Vol. 43 No. 3 March 1969, pp. 377-382
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FAMILIAL NEUROBLASTOMA WITH REGRESSION AND MATURATION TO GANGLIONEUROFIBROMA

Max E. Griffin M.D.1 and Robert P. Bolande M.D.1

1 Department of Pediatrics and Pathology, The Children's Hospital of Akron, Akron, Ohio

Two sisters with congenital disseminated neuroblastoma are reviewed clinically and pathologically. Both showed regression of their retroperitoneal tumors to fibrocalcific residues and maturation to ganglioneuroma. In one case, metastatic tumor nodules of the skin, which had matured to ganglioneuroma, through continued loss of ganglion cells came to closely resemble neurofibromas. A similarity to von Recklinghausen's disease became apparent. The question of a genetic basis for neuroblastoma and its relationship to von Recklinghausen's disease is discussed.

Submitted on August 6, 1968
Accepted on November 9, 1968




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