PEDIATRICS Vol. 43 No. 2 February 1969, pp. 277-283
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ADRENAL FUNCTION, GROWTH, AND INSULIN IN PATIENTS TREATED WITH CORTICOIDS ON ALTERNATE DAYS

Abdollah Sadeghi-Nejad M.S., M.D.1 and Boris Senior M.B., M.R.C.P.1

1 Department of Pediatrics, Tufts University School of Medicine, and Pediatric Endocrine-Metabolic Service, New England Medical Center Hospitals, (Boston Floating Hospital for Infants and Children), Boston

Fourteen children treated with corticosteroids in a single dose on alternate days for periods of up to 50 months were studied. None had a Cushingoid appearance. Growth was normal or accelerated in 12 of the children. The concentration of growth hormone in the serum and its maximal increase after insulin were like those of normal children. Regulation of the secretion of cortisol as judged by the response to insulin was depressed on the day when the corticoid was given, but it was nearly normal 28 hours later. The concentration of insulin in the serum was slightly higher in the treated than in the normal children.

Submitted on July 11, 1968
Accepted on September 16, 1968




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