PEDIATRICS Vol. 43 No. 1 January 1969, pp. 122-124
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Screening Test for the Diagnosis of Chronic Granulomatous Disease

Richard B. Johnston JR. M.D.1

1 Department of Medicine Children's Hospital Medical Center, and Department of Pediatrics Harvard Medical School 300 Longwood Avenue Boston, Massachusetts, 02115

Normal phagocytes suspended in plasma when mixed with latex particles for ingestion and nitroblue tetrazolium dye will reduce the dye to a blue color which may be easily seen in a test tube. This reaction depends on the release of enzymes from phagocytic lysosomal granules after phagocytosis. Since such release is deficient in patients with CGD, no blue color develops in the tube. This has proved to be a simple, reliable, screening test which should allow the more rapid and widespread diagnosis of CGD.